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Pharmaceutical intermediates

  • Procaine base

Procaine base

  • CAS NO:59-46-1
  • Molecular Formula: C13H20N2O2
  • Appearance:White to off white crystalline powder
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Product Details:

CAS No59-46-1

Formula: C13H20N2O2

Molecular weight: 236.31

Appearance: White to off white crystalline powder

Assy≥: 99%

Standard:Manufacturer's standard

Melting  point: 59~62℃

PH:5.5-8.5

Pharmaceutical Synthesis: API intermediate

Package specifications: 25kg package or packages provided according to user requirements.

Storage conditions: Sealed package storage in a dry and cool place, away from fire, and separated from alkaline compounds such as organic amines.

Synonyms:2-(Diethylamino)ethyl 4-aminobenzoate;2-(Diethylamino)ethyl p-aminobenzoate;2-(diethylamino)ethylp-aminobenzoate;2-diethylaminoethyl4-aminobenzoate;2-Diethylaminoethylester kyseliny p-aminobenzoove;2-diethylaminoethylesterkyselinyp-aminobenzoove;2-diethylaminoethylp-aminobenzoate;4-Aminobenzoic acid diethylaminoethyl ester
PROCAINE Usage And Synthesis
Description:Procaine is a local anesthetic with a para-amino function. Sensitization mainly concerns medical, dental and veterinary professions.
Chemical Properties:The hydrochloride salt of 2-(diethylamino) ethyl p-aminobenzoate (C13H21ClN2O2 or N2C6H4COOCH2CH2NH(C2H5)2HCl) is generally referred to as procaine. Although the PABA ester is insoluble in water, the hydrochloride salt is very soluble in water.
Uses1:Procaine (Novocain) is mainly used in dental or medical procedures requiring infiltration anesthesia, peripheral block, or spinal block.
Uses2:inhibitor of sodium channel
Definition ChEBI: A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.
Brand name:Novocain (Hospira).
Biological Functions:Procaine hydrochloride (Novocain) is readily hydrolyzed by plasma cholinesterase, although hepatic metabolism also occurs. It is not effective topically but is employed for infiltration, nerve block, and spinal anesthesia. It has a relatively slow onset and short (1 hour) duration of action. All concentrations can be combined with epinephrine. It is available in dental cartridges with phenylephrine as the vasoconstrictor.
General Description Procaine was synthesized in 1904 to address the chemical instabilityof cocaine and the local irritation it produced. The pKa of procaine is 8.9; it has low lipid solubility and the estergroup is unstable in basic solutions. Procaine is available inconcentrations ranging from 0.25% to 10% with pHs adjustedto 5.5 to 6.0 for chemical stability. Procaine is also includedin some formulations of penicillin G to decrease the pain ofintramuscular injection.
Contact allergens:Procaine is a local anesthetic with para-amino function. Sensitization mainly concerns the medical, dental, and veterinary professions.
Clinical Use:Procaine is very quickly metabolizedin the plasma by cholinesterases and in the liver via ester hydrolysisby a pseudocholinesterase. The in vitroelimination half-life is approximately 60 seconds. Any conditionthat decreases the cholinesterase concentration may increaseexposure to procaine and potential toxicity. Decreasedenzyme activity can be found with genetic deficiency, liverdisease, malignancy, malnutrition, renal failure, burns, thirdtrimester of pregnancy, and following cardiopulmonary bypasssurgery. Ester hydrolysis produces PABA, the compoundresponsible for the allergic reactions common to theester anesthetics. Procaine is not used topically because of itsinability to pass through lipid membranes and finds use as aninfiltration agent for cutaneous or mucous membranes, forshort procedures. Procaine is also used for peripheral nerveblock and as an epidural agent to diagnose pain syndromes.
Purification Methods:Procain crystallises as the dihydrate from aqueous EtOH and as the anhydrous material from pet ether or diethyl ether. The latter is hygroscopic. 
Procaine base manufacturer Located in Jiangyang District, Luzhou City. Ruilan chemical Co.,Ltd is a comprehensive high-tech modern enterprises integrating professional R&D, production and sales in medicine/ pesticide, intermediates . And expand the scope of commodity business along with the continuous development of the market.
The company has 1 production plant, has close cooperation with multiple manufacturers.At present, we mainly engaged in the research and development of procaine base . The the procaine base hatching has been put into the domestic and international market. Enterprises in many countries such as Europe, Russia and South America.The product have been widely applied, and the products are well received by customers.
The company has 1 research teams, 2 domestic and international trade teams, the total number of employees is 20.
The company "Customer first, Scientific management, Self-improvement, Seeking for excellence" as the managing concept," responsibility ,Trust" as our rule of activities. Besides persisting in the management philosophy of service excellent and sincerity first, Sunchem carried out a new strategy of development, as “trade main, industry basic, trade and industry interactive”, business scope and economic strength have continuous developing.